Umbilical cord blood not the right indicator to measure allergy risk

Wednesday, October 6, 2010

WASHINGTON - While testing blood samples from the umbilical cords of newborn babies to assess the risk of allergy, researchers have found that the biomarker in the blood that indicates the risk factor for allergy often comes from the mother rather than her baby.

Allergies occur when the defence mechanisms of the immune system malfunction and misread normal substances entering the body as invading pathogens.

Antibodies are part of our biochemical arsenal for combating viruses, bacteria, parasites and other alien substances, but during an allergic reaction the antibody, known as IgE, is directed against usually harmless substances such as grass pollen, nuts, pets or eggs.

New parents have previously been asked if they would like hospitals to assess the risk their babies run of developing allergies in childhood.

Hospitals tests the risk by measuring the amount of IgE in the blood of the umbilical cord, and use the results to determine the need for allergy prophylaxis, e.g. whether babies need a special allergy-friendly milk substitute.

However, researchers from COPSAC (Copenhagen Studies on Asthma in Childhood) at the Faculty of Health Sciences, University of Copenhagen recently discovered indications that IgE in the blood of the umbilical cord could originate from the mother, and decided to conduct a focused study on this.

They measured the total amount if IgE in the blood of the umbilical cord in 243 new-borns.

The researchers subsequently determined how much IgE originated from the mother by using hypersensitive analyses of IgE in the blood of the umbilical cord, blood from the mother, and blood from the baby six months after birth.

“We discovered that approximately half of the tests with increased IgE levels in the umbilical blood were due to IgE from the mother,” said Dr. Klaus Bonnelykke,.

“This may explain why many studies have shown poor results from the use of umbilical cord IgE. In future, if we want to use blood from the umbilical cord to assess the risk of an infant developing asthma or allergy we need to take the transfer of IgE from the mother into account. Or we will need to find another method,” he added.

The discovery has been published in the Journal of Allergy and Clinical Immunology. (ANI)

Filed under: Science and Technology

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