Asthma medication may help multiple sclerosis patients

WASHINGTON - Albuterol, a compound commonly used to treat asthma and other respiratory diseases, may benefit patients with multiple sclerosis, according to a new study.

Multiple sclerosis (MS) is a chronic inflammatory disease characterized by the degeneration of myelin, which coats nerve cells in the white matter of the central nervous system.

Patients with the condition have been found to have elevated levels of interleukin-12, a biological compound that promotes the generation of a type of helper T cell that may be associated with myelin destruction.

Albuterol sulfate-commonly used to treat bronchospasm, a constriction of the airways within the lungs as often occurs in asthma-may decrease interleukin-12 levels, the authors note.

Samia J. Khoury, of Brigham and Women’s Hospital and Harvard Medical School, Boston, and colleagues assessed the effects of albuterol treatment as an add-on therapy for patients starting treatment with glatiramer acetate, currently approved as a therapy for relapsing-remitting MS.

A total of 44 patients were randomly assigned to receive daily subcutaneous (underneath the skin) 20-milligram injections of glatiramer acetate plus either an oral dose of 4 milligrams of albuterol or placebo daily for two years.

Participants were examined by a neurologist at the beginning of the study and at six, 12, 18 and 24 months, and blood samples were collected at the beginning and three, six and 12 months into the study.

Magnetic resonance imaging (MRI) of the brain was performed at enrollment, 12 months and 24 months.

A total of 39 patients participated long enough to contribute to the analysis.

In assessments of functional status, improvement was observed in the glatiramer acetate plus albuterol group compared with the placebo group at six months and 12 months but not at 24 months.

Compared to patients taking placebo, those taking albuterol also experienced a delay in the time to their first relapse.

“We conclude that treatment with glatiramer acetate plus albuterol is well tolerated and improves clinical outcomes in patients with multiple sclerosis. The combined regimen seems to enhance clinical response during the first year of therapy,” the authors said.

The study appears in the September issue of Archives of Neurology, one of the JAMA/Archives journals. (ANI)