Vitamin D protects obese women against endometrial cancer

WASHINGTON - Obese women can reduce their increased risk of endometrial disease if they take vitamin D supplements, a new animal study has revealed.

Researchers at the Georgetown Lombardi Comprehensive Cancer Centre said that 25 percent of obese mice fed a vitamin D supplemented diet developed endometrial cancer, while 67 percent of obese mice not treated with the vitamin developed cancer.

They also said that vitamin D offered no protective effects for normal weight mice; whether or not they used the vitamin, about 60 percent of these mice developed cancer.

All of the mice were genetically predisposed to develop endometrial cancer, because they were missing one of their two PTEN tumour suppressor genes, loss of which is strongly linked to development of human endometrial cancer.

“Vitamin D has been shown to be helpful in a number of cancers, but for endometrial cancer, our study suggests it protects only against cancer that develops due to obesity,” said study’s lead investigator, Leena Hilakivi-Clarke.

“Still, if these results are confirmed in women, use of vitamin D may be a wonderfully simple way to reduce endometrial cancer risk.

“Until further studies are done, I think the best advice for women concerned about their risk is to take vitamin D supplements or spend a few more minutes each week in the sun. This vitamin has shown many health benefits in addition to the promise suggested by our mouse study,” she said.

While previous studies of women have demonstrated that obesity increases endometrial cancer risk by 2-fold or more and recurrence by up to 6-fold, recent research published by the National Institutes of Health on the protective effects of vitamin D on endometrial cancer showed no overall benefit.

But the study did not investigate whether vitamin D was effective in obese women, Hilakivi-Clarke said.

Therefore, in this study, researchers keyed in on a potential link between weight, a known endometrial cancer risk factor, and vitamin D, a potential reducer of risk in many cancers.

They used the best animal model available to look at endometrial cancer - the PTEN knock-out mice.

The research team, which included investigators from the National Cancer Institute, Northwestern University, Wake Forest University School of Medicine, and Walter Reed Hospital, divided their PTEN- mice into four groups.

One group was fed a normal diet and one received a normal diet with supplements of vitamin D. Another group was fed a high-fat diet, and the fourth group received a high fat diet plus vitamin D.

They found that in the mice fed a normal diet, the use of vitamin D had no effect on the development of endometrial cancer - about 60 percent of mice in both groups developed the cancer.

And 67 percent of mice that became obese from a high fat diet developed the cancer, while only 25 percent of obese mice that also received vitamin D developed endometrial cancer.

The findings were published in the Cancer Prevention Research. (ANI)