Excerpts from the citation for the 2010 Nobel Prize in chemistry

Excerpts from 2010 Nobel chemistry prize citation

Excerpts from the citation awarding the 2010 Nobel Prize in chemistry jointly shared by Ei-ichi Negishi and Akira Suzuki, Japan, and Richard Heck, United States, for the development of palladium-catalyzed cross coupling. This chemical tool has vastly improved the possibilities for chemists to create sophisticated chemicals.

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Carbon-based (organic) chemistry is the basis of life and is responsible for numerous fascinating natural phenomena: colour in flowers, snake poison and bacteria killing substances such as penicillin. Organic chemistry has allowed man to build on nature’s chemistry; making use of carbon’s ability to provide a stable skeleton for functional molecules. This has given mankind new medicines and revolutionary materials such as plastics.

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In order to create these complex chemicals, chemists need to be able to join carbon atoms together. However, carbon is stable and carbon atoms do not easily react with one another. The first methods used by chemists to bind carbon atoms together were therefore based upon various techniques for rendering carbon more reactive. Such methods worked when creating simple molecules, but when synthesizing more complex molecules chemists ended up with too many unwanted by-products in their test tubes.

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Palladium-catalyzed cross coupling solved that problem and provided chemists with a more precise and efficient tool to work with. In the Heck reaction, Negishi reaction and Suzuki reaction, carbon atoms meet on a palladium atom, whereupon their proximity to one another kick-starts the chemical reaction.

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Palladium-catalyzed cross coupling is used in research worldwide, as well as in the commercial production of for example pharmaceuticals and molecules used in the electronics industry.