Specific changes in the brain linked to sleep deprivation

WASHINGTON - Scientists have published the most systematic study to date of the effects of sleep deprivation on gene expression in the brain.

The findings have implications for improving the understanding and management of the adverse effects of sleep deprivation on brain function.

The study, available in Frontiers in Neuroscience, has created an extensive and detailed map of gene activity, known as gene expression, in the mouse brain across five behavioral conditions including sleeping, waking and sleep deprivation.

“This pioneering study documents how extending wakefulness affects gene expression in specific brain regions and describes a ‘molecular anatomical signature’ of sleep deprivation,” said Thomas Kilduff, senior director of the Center for Neuroscience at SRI International.

“Our findings may contribute to treatments that will help improve sleep quality and reduce problems arising from sleep deprivation.”

By comparing which genes were turned on and where in the brain across the different conditions, the researchers discovered that the majority of the neurons in the forebrain were affected in diverse ways by sleep deprivation, painting a dynamic picture of the molecular consequences of sleep deprivation on higher cognitive functions.

Affected forebrain regions include the neocortex, amygdala and hippocampus, which mediate cognitive, emotional and memory functions that are impaired by sleep deprivation.

Detailed analysis of 209 brain areas revealed a novel set of genes not previously associated with sleep deprivation, including genes associated with the stress response, cell-cell signaling, and the regulation of other genes.

One gene, neurotensin, has been implicated in schizophrenia and is similarly induced by antipsychotic drugs.

These genes may provide potential targets for therapeutic intervention to alleviate the effects of sleep deprivation. (ANI)