Alzheimer’s risk increases with maternal inheritance
By ANITuesday, November 16, 2010
WASHINGTON - It is well known that individuals with a parental history of Alzheimer’s are at increased risk for developing the disorder, but a new study suggests that which of the parents has the disease is very important.
Researchers also said that the specific biological and genetic mechanisms accounting for this increased risk are not known.
An important consideration may be a phenomenon called genomic imprinting, where the pattern of the inherited disease differs based on whether the risk genes are inherited from the mother or the father.
Imprinting is a type of epigenetic regulation, meaning that long lasting changes in gene function are produced through regulatory mechanisms rather than by altering the sequence of the DNA.
In this new study, researchers set out to evaluate Alzheimer’s risk in healthy, cognitively normal individuals by measuring their cerebrospinal fluid proteins, which are known to be altered in Alzheimer’s.
They compared individuals with a maternal or paternal history of Alzheimer’s to individuals with no family history.
Only individuals whose mothers had Alzheimer’s showed altered levels of a protein called amyloid, a major hallmark of Alzheimer’s pathology, as well as proteins involved with oxidative stress (i.e., free radicals, which are harmful to the brain as well as the rest of the body). In contrast, individuals whose fathers had Alzheimer’s and those with no family history had protein levels within normal range.
“Our data indicate that adult children of mothers with Alzheimer’s may be at increased risk for developing the disease,” explained Dr. Lisa Mosconi, the first author on the study.
“It is therefore extremely important to understand the genetic mechanisms involved in maternal transmission of Alzheimer’s disease, which are currently unknown. Identifying a genetic predictor for the disease might lead to preventive treatments years before the onset of clinical symptoms.”
The study has been published in the journal Biological Psychiatry. (ANI)
