Body’s own proteins could help in global fight against tuberculosis

WASHINGTON - Taking help from proteins in our bodies, Ohio scientists are trying to fight the re-emerging threat of tuberculosis (TB).

They have found that the protein CCL5 plays a protective role in helping the body ward off this contagious, airborne disease in the early stages of infection.

CCL5 is a member of a large family of proteins responsible for immune cell migration toward infection sites.

The work on this molecule suggests that CCL5 and/or related proteins may lead to new therapies that help the immune system resist TB.

“We hope this study will spark interest in understanding the mechanisms which control cell migration to sites of infection, help define the protective immune response to Mycobacterium tuberculosis, and ultimately improve our capacity to predict and/or treat patients with TB,” said Dr. Gillian Beamer, who was involved in the work.

Scientists discovered the role and potential benefits of CCL5 by studying mice lacking the gene to make the CCL5 protein and mice with the CCL5 gene.

When both groups of mice were infected with Mycobacterium tuberculosis, those lacking CCL5 accumulated fewer protective cells and had more bacteria in the lungs over three to five weeks of infection when compared to the normal mice.

After five weeks, differences between the groups were not apparent, leading researchers to conclude that CCL5 did not play a role in long-term infection, but rather in the onset and early protection against infection.

Additionally, in humans, altered CCL5 expression may be a predisposing factor leading to TB disease progression.

The study has been published in the Journal of Leukocyte Biology. (ANI)