2 Japanese, American share chemistry Nobel for cross couplings

2 Japanese, American share chemistry Nobel

STOCKHOLM — An American and two Japanese scientists won the 2010 Nobel Prize in chemistry on Wednesday for developing a chemical method that has allowed scientists to make potential cancer drugs and other medicines as well as slimmed-down computer screens.

Richard Heck, Ei-ichi Negishi and Akira Suzuki were honored for their development of one of the most sophisticated tools available to chemists today, called palladium-catalyzed cross couplings.

The method is used by researchers worldwide and in commercial production of pharmaceuticals and molecules used to make electronics, the Royal Swedish Academy of Sciences said.

Heck, 79, is a professor emeritus at the University of Delaware. Negishi, 75, is a chemistry professor at Purdue University in West Lafayette, Indiana, and 80-year-old Suzuki is a professor at Hokkaido University in Sapporo, Japan.

Negishi told reporters in Stockholm by telephone that he was asleep when the call came.

“I went to bed last night well past midnight so I was sleeping but I am extremely happy to receive the telephone call,” he said.

Officials at Hokkaido University were delighted by the news, said university spokesman Hidetoshi Nakatsuka.

“Professor Suzuki has been mentioned as a candidate in the past few years and we’ve been waiting for this to happen for all these years,” Nakatsuka said. “We were standing by and we are extremely delighted.”

Japanese Prime Minister Naoto Kan said he spoke to Suzuki on the phone and congratulated him.

“He told me that Japan’s science and technology is at the world’s top level and encouraged me to make good use of the resources,” Kan said.

The method developed by the Nobel winners has been used to artificially produce cancer-killing substances first found in marine sponges, the academy said in its citation. While clinical testing has started, it’s not yet clear whether they will turn out to be useful drugs.

It’s also being used to create new antibiotics that work on resistant bacteria and a number of commercially available drugs, including the anti-inflammatory Naproxen, prize committee member Claes Gustafsson said.

“There have been calculations that no less than 25 percent of all chemical reactions in the pharmaceutical industry are actually based on these methods,” Gustafsson said.

Palladium-catalyzed cross coupling has also been used by the electronics industry to make light-emitting diodes used in the production of extremely thin monitors, the academy said.

The 2010 Nobel Prize announcements began Monday with the medicine award going to 85-year-old British professor Robert Edwards for fertility research that led to the first test tube baby.

Russian-born Andre Geim, 51, and Konstantin Novoselov, 36, of the University of Manchester in England won the physics prize Tuesday for groundbreaking experiments with graphene, an ultrathin and superstrong material that scientists say should be a versatile building block for faster computers, transparent touch screens and lighter airplanes.

The literature prize will be announced on Thursday, followed by the peace prize on Friday and economics on Monday, Oct. 11.

The awards were established by Swedish industrialist Alfred Nobel — the inventor of dynamite — and are always handed out on Dec. 10, the anniversary of his death in 1896.

Associated Press Writers Louise Nordstrom in Stockholm and Mari Yamaguchi and Jay Alabaster in Tokyo contributed to this report.