Endurance exercise thwarts premature aging

WASHINGTON - A study by McMaster University researchers has found that endurance exercise may stop you looking and feeling old, it may even help you live longer.

“We have clearly shown that there is no substitute for the “real thing” of exercise when it comes to protection from aging,” said Mark Tarnopolsky, principal investigator of the study and a professor of pediatrics and medicine of the Michael G. DeGroote School of Medicine.

The study found that premature aging in nearly every organ in the body was completely prevented in mice that ran on a treadmill three times a week for five months.

Mitochondria are unique in that they have their own DNA. It has been thought that lifelong accumulation of mitochondrial DNA mutations lead to energy crisis that result in a progressive decline in tissue and organ function, ultimately resulting in aging. But the study on genetically-disadvantaged mice found those who had endurance exercise training three times a week looked as young as healthy mice while their sedentary siblings were balding, graying, physically inactive, socially isolated and less fertile.

“Others have tried to treat these animals with “exercise pill” drugs and have even tried to reduce their caloric intake, a strategy felt to be the most effective for slowing aging, and these were met with limited success,” said Tarnopolsky.

Adeel Safdar, lead author and a senior PhD student working with Tarnopolsky said: “I believe that we have very compelling evidence that clearly show that endurance exercise is a lifestyle approach that improves whole body mitochondrial function which is critical for reducing morbidity and mortality. Exercise truly is the fountain of youth.”

Co-author Jacqueline Bourgeois said: “The recipe for healthy aging is very simple, and that’s exercise. The problem is that it is most people find it a difficult recipe to follow.” The study has been published in the prestigious science journal Proceedings of the National Academy of Sciences (PNAS). (ANI)