Human stem cells from fat tissue successfully fuse with rat heart cells and beat

Tuesday, March 1, 2011

WASHINGTON - Scientists have successfully fused human stem cells derived from subcutaneous adipose (fat) tissue with muscle cells from rat hearts.

And, not only did these cells ‘talk’ to form new muscle cells altogether, but they actually beat, said researchers.

“Recovery of regenerative cells located in the stromal vascular fraction of a patient’s own subcutaneous tissue is relatively simple and can be used for self-healing,” said Christopher Alt, a researcher involved in the work from the Department of Molecular Pathology at the University of Texas in Houston.

“A patient’s quality of life can be improved by application of those recovered regenerative cells to the heart, as well as to bone, tendons, non-healing wounds and joints,” he said.

Using newborn rats, scientists studied the combination of rat heart muscle cells (cardiomyocytes) and human adipose (fat) stem cells derived from human subcutaneous adipose tissue.

They found that the two fused and formed new heart muscle cells with several nuclei. When kept in a culture environment, these cells beat. These new cells exhibited an ability to compensate for a loss of cardiomyocytes as following a myocardial infarction, via fusion with cardiomyocytes.

Furthermore, the study has shown that contrary to previous findings suggesting that genetic modification of certain embryonic genes in adult stem cells is required as a prerequisite for turning into heart cells, the human stem cells used in this study were not genetically modified.

The findings have been published in the FASEB Journal. (ANI)

Filed under: Science and Technology

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